Galectin-3 expression in thyroid tumors
نویسندگان
چکیده
منابع مشابه
Differential expression of galectin-3 in pituitary tumors.
Galectin-3 (Gal-3), a beta-galactoside-binding protein, has been implicated in a variety of biological functions, including cell proliferation and differentiation, tumor cell adhesion, angiogenesis, apoptosis, tumor progression, and metastasis. We investigated the role of Gal-3 in the development and progression of pituitary tumors. Immunohistochemical and Western blot analysis of normal and ne...
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INTRODUCTION It has been suggested that Galectin-3 (Gal-3) and Galectin-7 (Gal-7) are potential tumour markers for differentiating thyroid carcinoma from its benign counter part. Galectins are beta-galactoside-binding proteins with Gal-3 being a redundant pre-mRNA splicing factor. They are supposed to be p53-related regulators in cell growth and apoptosis, being either anti-apoptotic or pro-apo...
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1. Medical doctor; resident on Pathology, Hospital de Base do Distrito Federal (HBDF). 2. Chairman professor of Pathology, PhD in Pathology, Department of Pathology, Universidade de Brasília (UnB). Work developed at the Laboratory of Pathology, Faculty of Medicine, Universidade de Brasília, and supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Empree...
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Galectin-3 is a glycan-binding protein that mediates cell-cell and/or cell-extracellular matrix (ECM) interactions. Although galectin-3 is implicated in the progression of various types of cancers, the mechanisms by which galectin-3 enhances metastasis remain unclear. In order to elucidate the role of galectin-3 in the complex multistage process of cancer metastasis, we examined galectin-3 and ...
متن کاملNoninvasive In Vivo Imaging and Biologic Characterization of Thyroid Tumors by ImmunoPET Targeting of Galectin-3.
The high prevalence of thyroid nodules in the adult population and the relatively low incidence of thyroid cancer make the preoperative identification of malignant lesions challenging. The β-galactoside-binding protein galectin-3 is widely expressed in well-differentiated thyroid carcinomas, but not in normal thyrocytes and benign thyroid nodules. This molecule offers a candidate biomarker to i...
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ژورنال
عنوان ژورنال: Scripta Scientifica Medica
سال: 2016
ISSN: 1314-6408,0582-3250
DOI: 10.14748/ssm.v48i3.1739